Switch from Mounjaro to Wegovy? Top Tips to make it easy

Guidance from our Prescribing Pharmacists

Changing from one GLP-1 medicine to another can feel like a big step — but with tailored prescribing and supportive follow-up, most people find the transition smooth and sustainable. At The Health Dispensary, our prescribing pharmacists help you switch from Mounjaro (tirzepatide) to Wegovy (semaglutide) in a way that reflects your health history, goals and day-to-day life.

Why people switch — and why it should be personalised

Both medicines support weight management by acting on appetite and blood-sugar regulation, but they are not identical. Mounjaro acts on both GLP-1 and GIP receptors, while Wegovy focuses solely on GLP-1. Those differences mean the experience of switching varies from person to person.

Common reasons for switching include tolerance, supply or cost changes, a weight-loss plateau, or a prescriber’s clinical recommendation. Whatever your reason, we’ll design a plan that suits you — not a one-size-fits-all timetable.

How our prescribing pharmacists support your switch

• Clinical review: we consider your medical background, previous dosing, side-effect history, and goals.
• Timing & dosing: we advise on the right interval between your last Mounjaro dose and first Wegovy dose, and a starting dose that matches your tolerance.
• Follow-up & monitoring: structured check-ins to review appetite, digestion, weight trends, sleep and energy — not just the number on the scales.
• Whole-health coaching: simple nutrition, hydration and activity guidance to ease side effects and support results.

Practical tips to help your body adjust

• Hydrate steadily: sip water through the day (around 2 litres for most adults) rather than in big bursts.
• Eat mindfully: smaller portions, chew slowly, pause at comfortable fullness; avoid grazing but don’t skip meals.
• Keep meals balanced: prioritise lean proteins, colourful veg and fibre (e.g. oats, chia, wholegrains) to support digestion.
• Plan lighter food on injection days: soups, eggs or fish can be gentler; avoid heavy, sugary or very fatty meals and alcohol initially.
• Move gently: walking, yoga or light strength work can help energy, mood and bowel regularity.
• Track how you feel: note appetite, sleep, energy and any gastric symptoms to discuss at review.

When to get extra advice

Mild nausea or constipation often settles as your body adapts and we can help you treat these often with NHS care. If you experience persistent vomiting, severe abdominal pain, signs of dehydration, or ongoing constipation despite self-care, seek medical attention.

Book an appointment

Prefer a pharmacist-prescribed, human approach to your GLP-1 journey? We’d love to help.

Book your review online or learn more about our service on our Weight Loss page.

FAQs

How long does it take to adjust after switching?
Everyone is different, but many people feel settled within 2–4 weeks as dose and routine are optimised.

Is the starting dose the same for everyone?
No — starting doses are individual and depend on your history and tolerance. We’ll recommend what’s right for you.

What if I feel hungrier at first?
That can happen while your body adapts. Mindful eating, balanced meals and steady hydration usually help; we’ll review your dose and timing at follow-up.

Can I mix or overlap doses?
Don’t overlap without clinical advice. We’ll confirm safe timing between your last Mounjaro dose and your first Wegovy dose.